Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit
fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental …

The best global seller among oncology drugs in 2018 is lenalidomide, an analog of
thalidomide. It took 53 years and a circuitous route from the discovery of thalidomide to …

Aging is a complex phenomenon caused by the time-dependent loss of cellular
homeodynamics and consequently of physiological organismal functions. This process is …

Autophagy is a lysosome-dependent intracellular degradation pathway that has been
implicated in the pathogenesis of various human diseases, either positively or negatively …

Drosophila melanogaster (fruit fly) is an animal model chassis in biological and genetic
research owing to its short life cycle, ease of cultivation, and acceptability to genetic …

Drosophila melanogaster has been for over a century the model of choice of several
neurobiologists to decipher the formation and development of the nervous system as well as …

Friedreich ataxia (FRDA) is the most important autosomal recessive ataxia in the Caucasian
population. FRDA patients display severe neurological and cardiac symptoms that reflect a …

Neurodegenerative diseases (NDs) constitute a very important problem in our current
society, as they are usually associated with the aging process. NDs are devastating …

Friedreich's ataxia (FRDA) is a rare inherited recessive disorder affecting the central and
peripheral nervous systems and other extraneural organs such as the heart and pancreas …