This year marks the tenth anniversary of cell therapy with chimeric antigen receptor (CAR)-
modified T cells for refractory leukemia. The widespread commercial approval of genetically …

Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Diabetes has been a worldwide healthcare problem for many years. Current methods of
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …

The coding variant (p. Arg192His) in the transcription factor PAX4 is associated with an
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …

Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …

Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-
associated diseases. However, there are no scalable approaches to comprehensively …

Aging is a major risk factor for multiple diseases, including cardiovascular diseases,
neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the …

Stem cell-derived islets (SC-islets) offer the potential to be an unlimited source of cells for
disease modeling and the treatment of diabetes. SC-islets can be genetically modified …