Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis

D Dhakal, V Rayamajhi, R Mishra… - Journal of Industrial …, 2019 - academic.oup.com
Nocardia spp. are catalase positive, aerobic, and non-motile Gram-positive filamentous
bacteria. Many Nocarida spp. have been reported as unusual causes of diverse clinical …

[HTML][HTML] Natural products from Nocardia and their role in pathogenicity

A Engelbrecht, H Saad, H Gross, L Kaysser - Microbial Physiology, 2021 - karger.com
Nocardia spp. are filamentous Actinobacteria of the order Corynebacteriales and mostly
known for their ability to cause localized and systemic infections in humans. However, the …

Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product

S Kishore, A Del Rio Flores, SR Lynch… - Journal of the …, 2024 - ACS Publications
The genomes of 40 strains of Nocardia, most of which were associated with life-threatening
human infections, encode a highly conserved assembly line polyketide synthase designated …

Toward a genetic system in the marine cyanobacterium Prochlorococcus

R Laurenceau, C Bliem, MS Osburne… - Access …, 2020 - microbiologyresearch.org
As the smallest and most abundant primary producer in the oceans, the cyanobacterium
Prochlorococcus is of interest to diverse branches of science. For the past 30 years …

Enhanced production of nargenicin A1 and creation of a novel derivative using a synthetic biology platform

D Dhakal, AK Chaudhary, JS Yi, AR Pokhrel… - Applied microbiology …, 2016 - Springer
Nargenicin A1, an antibacterial produced by Nocardia sp. CS682 (KCTC 11297BP),
demonstrates effective activity against various Gram-positive bacteria. Hence, we attempted …

Characterization of tailoring steps of nargenicin A1 biosynthesis reveals a novel analogue with anticancer activities

D Dhakal, JM Han, R Mishra, RP Pandey… - ACS Chemical …, 2020 - ACS Publications
Nargenicin A1 (1) is an antibacterial macrolide with effective activity against various Gram-
positive bacteria, including methicillin-resistant Staphylococcus aureus. Due to the …

[HTML][HTML] Clinical Nocardia species: identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China

SH Lu, ZW Qian, PP Mou, L Xie - Bosnian Journal of Basic Medical …, 2020 - ncbi.nlm.nih.gov
Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to
investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of …

Improved production of 1-deoxynojirymicin in Escherichia coli through metabolic engineering

V Rayamajhi, D Dhakal, AK Chaudhary… - World Journal of …, 2018 - Springer
Abstract Azasugars, such as 1-deoxynojirymicin (1-DNJ), are associated with diverse
pharmaceutical applications, such as antidiabetic, anti-obesity, anti-HIV, and antitumor …

[HTML][HTML] Genome Mining and Genetic Manipulation Reveal New Isofuranonaphthoquinones in Nocardia Species

PB Poudel, D Dhakal, RT Magar, N Parajuli… - International Journal of …, 2024 - mdpi.com
The identification of specialized metabolites isolated from microorganisms is urgently
needed to determine their roles in treating cancer and controlling multidrug-resistant …

Production of a Novel Tetrahydroxynaphthalene (THN) Derivative from Nocardia sp. CS682 by Metabolic Engineering and Its Bioactivities

R Mishra, D Dhakal, JM Han, HN Lim, HJ Jung… - Molecules, 2019 - mdpi.com
Nargenicin A1 is major secondary metabolite produced by Nocardia sp. CS682, with an
effective antibacterial activity against various Gram-positive bacteria. Most Nocardia spp …