Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

The post-translational attachment of one or several ubiquitin molecules to a protein
generates a variety of targeting signals that are used in many different ways in the cell …

The UCH37 deubiquitylase functions in two large and very different complexes, the 26S
proteasome and the INO80 chromatin remodeler. We have performed biochemical …

Protein ubiquitination and deubiquitination participate in a number of biological processes,
including cell growth, differentiation, transcriptional regulation, and oncogenesis. Ubiquitin C …

Deubiquitinating enzymes (DUBs), capable of removing ubiquitin (Ub) from protein
substrates, are involved in numerous biological processes. The ubiquitin C-terminal …

Spontaneous folding of a polypeptide chain into a knotted structure remains one of the most
puzzling and fascinating features of protein folding. The folding of knotted proteins is on the …

Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37,
one of the proteasome's three deubiquitinating enzymes. We have determined the structure …

The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

In the last decade, a new class of proteins has emerged that contain a topological knot in
their backbone. Although these structures are rare, they nevertheless challenge our …

In all eukaryotic cells, 26S proteasome plays an essential role in the process of ATP-
dependent protein degradation. In this review, we focus on structure characterization of the …