[HTML][HTML] An overview of myopia genetics
XB Cai, SR Shen, DF Chen, Q Zhang, ZB Jin - Experimental eye research, 2019 - Elsevier
Myopia is one of the leading ocular disorders causing visual impairment worldwide, with the
prevalence increasing rapidly. It's a significant global public health concern in 21st century …
prevalence increasing rapidly. It's a significant global public health concern in 21st century …
The genetic basis for adult onset glaucoma: recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
H Choquet, RB Melles, D Anand, J Yin… - Nature …, 2021 - nature.com
Cataract is the leading cause of blindness among the elderly worldwide and cataract
surgery is one of the most common operations performed in the United States. As the …
surgery is one of the most common operations performed in the United States. As the …
Update on the genetics of primary open-angle glaucoma
Affecting nearly 80 million individuals, glaucoma is the number one cause of irreversible
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
Molecular genetics of glaucoma: Subtype and ethnicity considerations
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …
differential presentation as well as ethnic and geographic disparities. The multifactorial …
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus
Keratoconus is characterised by reduced rigidity of the cornea with distortion and focal
thinning that causes blurred vision, however, the pathogenetic mechanisms are unknown. It …
thinning that causes blurred vision, however, the pathogenetic mechanisms are unknown. It …
Update on the genetics of keratoconus
Y Bykhovskaya, YS Rabinowitz - Experimental Eye Research, 2021 - Elsevier
In the past few years we have seen a great acceleration of discoveries in the field of
keratoconus including new treatments, diagnostic tools, genomic and molecular …
keratoconus including new treatments, diagnostic tools, genomic and molecular …
Clinical implications of recent advances in primary open-angle glaucoma genetics
H Choquet, JL Wiggs, AP Khawaja - Eye, 2020 - nature.com
Over the last decade, genetic studies, including genome-wide association studies (GWAS),
have accelerated the discovery of genes and genomic regions contributing to primary open …
have accelerated the discovery of genes and genomic regions contributing to primary open …
Transforming growth factor beta receptor 2 (Tgfbr2) deficiency in keratocytes results in corneal ectasia
YC Wang, OB Zolnik, S Yasuda, LK Yeh, Y Yuan… - The Ocular Surface, 2023 - Elsevier
Abstract Purpose We hypothesized that Transforming growth factor beta receptor 2 (Tgfbr2)
deletion in keratocyte (Tgfbr2 kera-cko), the corneal stroma cell, can result in corneal …
deletion in keratocyte (Tgfbr2 kera-cko), the corneal stroma cell, can result in corneal …
Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits
P Orchard, N Manickam, C Ventresca… - Genome …, 2021 - genome.cshlp.org
Skeletal muscle accounts for the largest proportion of human body mass, on average, and is
a key tissue in complex diseases and mobility. It is composed of several different cell and …
a key tissue in complex diseases and mobility. It is composed of several different cell and …