[HTML][HTML] Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

Y Wang, Y Chen, J Zhang, Y Yang, JS Fleishman… - Drug Resistance …, 2024 - Elsevier
Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Therapeutic strategies to overcome cisplatin resistance in ovarian cancer

M Song, M Cui, K Liu - European journal of medicinal chemistry, 2022 - Elsevier
Ovarian cancer (OC) is one of the most common gynecologic tumors worldwide and one
with the highest mortality. Cisplatin (DDP) is the first platinum-based complex approved by …

Metal complex-based liposomes: Applications and prospects in cancer diagnostics and therapeutics

Z Wang, J Li, G Lin, Z He, Y Wang - Journal of Controlled Release, 2022 - Elsevier
Metal complexes are of increasing interest as pharmaceutical agents in cancer diagnostics
and therapeutics, while some of them suffer from issues such as limited water solubility and …

Copper dithiocarbamates: coordination chemistry and applications in materials science, biosciences and beyond

G Hogarth, DC Onwudiwe - Inorganics, 2021 - mdpi.com
Copper dithiocarbamate complexes have been known for ca. 120 years and find relevance
in biology and medicine, especially as anticancer agents and applications in materials …

[HTML][HTML] Anticancer properties of complexes derived from bidentate ligands

DI Ugwu, J Conradie - Journal of Inorganic Biochemistry, 2023 - Elsevier
Cancer is the abnormal division and multiplication of cells in an organ or tissue. It is the
second leading cause of death globally. There are various types of cancer such as prostate …

Copper-plumbagin complex produces potent anticancer effects by depolymerizing microtubules and inducing reactive oxygen species and DNA damage

S Mukherjee, AV Sawant, SS Prassanawar… - ACS omega, 2023 - ACS Publications
Here, we have synthesized a copper complex of plumbagin (Cu-PLN) and investigated its
antiproliferative activities in different cancer cells. The crystal structure of Cu-PLN showed …

8-Hydroxyquinoline ruthenium (II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin

M Huang, Y Zhang, Y Gong, Z Liang, X Chen… - Journal of Inorganic …, 2023 - Elsevier
Ruthenium complexes are one of the most promising anticancer drugs triggered extensive
research. Here, the synthesis and characterization of two ruthenium (II) polypyridine …

Theoretical exploration on structures, bonding aspects and molecular docking of α-aminophosphonate ligated copper complexes against SARS-CoV-2 proteases

O Yadav, M Kumar, H Mittal, K Yadav… - Frontiers in …, 2022 - frontiersin.org
Recent years have witnessed a growing interest in the biological activity of metal complexes
of α-aminophosphonates. Here for the first time, a detailed DFT study on five α …

Copper as the target for anticancer nanomedicine

S Shao, J Si, Y Shen - Advanced Therapeutics, 2019 - Wiley Online Library
Microelements such as copper are essential and involved in various biological processes
and under strict homeostatic regulation. Compared to healthy individuals, cancer patients …

Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

A Mishra, KY Djoko, YH Lee, RM Lord, G Kaul… - Organic & …, 2023 - pubs.rsc.org
Copper Pyrithione,[Cu (PyS) 2] has shown excellent biological activity against cancer cells
and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability …