Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

Angiotensin II (Ang II), the biologically active component of renin-angiotensin system (RAS),
acts through two receptor subtypes, the AT1 and the AT2 receptor. All classic physiological …

Preeclampsia is an inflammatory disorder in which serum levels of vascular endothelial
growth factor (VEGF) and its soluble receptor-1 (sVEGFR-1, also known as sFlt-1) are …

During normal pregnancy, the renin–angiotensin system (RAS) plays a vitally important role
in salt balance and subsequent well-being of mother and fetus. In this balance, one must …

Background—Angiotensin II (Ang II) is implicated in cardiac remodeling and is increasingly
recognized for its profibrotic activity. Methods and Results—Because little is known about …

Preeclampsia is a hypertensive disorder unique to pregnancy with consistent involvement of
the kidney. The renin-angiotensin system (RAS) has been implicated in the pathogenesis of …

Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial
maternal and fetal morbidity and mortality. Recent evidence indicates that maternal …

Background Pregnancy is characterized by an inflammatory-like process and this may be
exacerbated in preeclampsia. The heme oxygenase (HO) enzymes generate carbon …

Preeclampsia (PE) is a pregnancy-specific syndrome characterized by hypertension,
proteinuria and edema, which resolves on placental delivery. It is thought to be the …

Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-
like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor …