Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

The organization of chromatin into higher-order structures influences chromosome function
and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated …

Abstract Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …

Distinct modifications of histone amino termini, such as acetylation, phosphorylation and
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …

Covalent modifications of histone tails have fundamental roles in chromatin structure and
function. One such modification, lysine methylation, has important functions in many …

The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

Histone H3 lysine 9 methylation has been proposed to provide a major" switch" for the
functional organization of chromosomal subdomains. Here, we show that the murine Suv39h …

Eukaryotic heterochromatin is characterized by a high density of repeats and transposons,
as well as by modified histones, and influences both gene expression and chromosome …