Leishmaniasis: prevention, parasite detection and treatment

T Kobets, I Grekov, M Lipoldova - Current Medicinal Chemistry, 2012 - ingentaconnect.com
Leishmaniasis remains a public health problem worldwide, affecting approximately 12
million people in 88 countries; 50 000 die of it each year. The disease is caused by …

Micro/nanoparticle adjuvants for antileishmanial vaccines: present and future trends

A Badiee, VH Shargh, A Khamesipour, MR Jaafari - Vaccine, 2013 - Elsevier
Leishmania infection continues to have a major impact on public health inducing significant
morbidity and mortality mostly in the poorest populations. Drug resistance, toxicity and side …

Guidelines for the purification and characterization of extracellular vesicles of parasites

C Fernandez‐Becerra, P Xander… - Journal of …, 2023 - Wiley Online Library
Parasites are responsible for the most neglected tropical diseases, affecting over a billion
people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible …

[HTML][HTML] Potency, Efficacy and Durability of DNA/DNA, DNA/Protein and Protein/Protein Based Vaccination Using gp63 Against Leishmania donovani in BALB/c Mice

S Mazumder, M Maji, A Das, N Ali - PloS one, 2011 - journals.plos.org
Background Visceral leishmaniasis (VL) caused by an intracellular protozoan parasite
Leishmania, is fatal in the absence of treatment. At present there are no effective vaccines …

DNA vaccines against protozoan parasites: advances and challenges

E Dumonteil - BioMed research international, 2007 - Wiley Online Library
Over the past 15 years, DNA vaccines have gone from a scientific curiosity to one of the most
dynamic research field and may offer new alternatives for the control of parasitic diseases …

[HTML][HTML] DNA immunization as an efficient strategy for vaccination

A Bolhassani, SR Yazdi - Avicenna journal of medical …, 2009 - ncbi.nlm.nih.gov
The field of vaccinology provides excellent promises to control different infectious and non-
infectious diseases. Genetic immunization as a new tool in this area by using naked DNA …

Prophylactic properties of a Leishmania‐specific hypothetical protein in a murine model of visceral leishmaniasis

DP Lage, VT Martins, MC Duarte, E Garde… - Parasite …, 2015 - Wiley Online Library
In this work, the effect of vaccination of a newly described Leishmania infantum antigenic
protein has been studied in BALB/c mice infected with this parasite species. The LiHyD …

Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in …

S Rafati, E Gholami, N Hassani, F Ghaemimanesh… - Vaccine, 2007 - Elsevier
Heat shock proteins (HSP) are highly conserved molecules that play important roles in
protein folding, assembly of protein complexes and translocation of proteins across cellular …

Immunogenicity and protective efficacy of a new Leishmania hypothetical protein applied as a DNA vaccine or in a recombinant form against Leishmania infantum …

PAF Ribeiro, DS Dias, DP Lage, VT Martins… - Molecular …, 2019 - Elsevier
Vaccination is one the most important strategies for the prevention of visceral leishmaniasis
(VL). In the current study, a new Leishmania hypothetical protein, LiHyP, which was …

Transmembrane proteins–mining the cattle tick transcriptome

SA Richards, C Stutzer, AM Bosman… - Ticks and tick-borne …, 2015 - Elsevier
Managing the spread and load of pathogen-transmitting ticks is an important task worldwide.
The cattle tick, Rhipicephalus microplus, not only impacts the economy through losses in …