Molecular diagnostics in the evaluation of thyroid nodules: current use and prospective opportunities

J Patel, J Klopper, EE Cottrill - Frontiers in endocrinology, 2023 - frontiersin.org
Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new
cases to be diagnosed in 2022 and representing the 7th most common cancer in women …

Molecular testing for thyroid nodules: the experience at McGill University teaching hospitals in Canada

M Rajab, RJ Payne, VI Forest, M Pusztaszeri - Cancers, 2022 - mdpi.com
Simple Summary The aim of this review is to provide a general overview about the
molecular markers (mutations and alterations) of thyroid cancers, present several molecular …

Real-world performance of the Afirma Genomic Sequencing Classifier (GSC)—a meta-analysis

CE Nasr, M Andrioli, M Endo, RM Harrell… - The Journal of …, 2023 - academic.oup.com
Abstract Context The Afirma® GSC aids in risk stratifying indeterminate thyroid nodule
cytology (ITN). The 2018 GSC validation study (VS) reported a sensitivity (SN) of 91 …

[HTML][HTML] Differentiated thyroid carcinoma: an update

P van Houten, RT Netea-Maier, JW Smit - Best Practice & Research …, 2023 - Elsevier
Differentiated thyroid carcinoma (DTC) is the most common endocrine cancer. Particularly
the incidence of small clinically indolent tumors has been increasing significantly during the …

A comprehensive study on the diagnosis and management of noninvasive follicular thyroid neoplasm with papillary-like nuclear features

BA Alzumaili, LN Krumeich, R Collins, T Kravchenko… - Thyroid, 2023 - liebertpub.com
Background: Since the noninvasive follicular thyroid neoplasm with papillary-like nuclear
features (NIFTPs) was introduced in 2016, most retrospective studies have included cases …

Update on molecular diagnostics in thyroid pathology: a review

B Alzumaili, PM Sadow - Genes, 2023 - mdpi.com
Thyroid nodules are quite common, and the determination of a nodule of concern is
complex, involving serum testing, radiology and, in some cases, pathological evaluation. For …

Indeterminate thyroid nodules: from cytology to molecular testing

P Vignali, E Macerola, AM Poma, R Sparavelli… - Diagnostics, 2023 - mdpi.com
Thyroid cancer is the most common malignancy of the endocrine system. Fine-needle
aspiration (FNA) biopsy of thyroid nodules has become the gold standard procedure, in …

Risk stratification of indeterminate thyroid nodules using ultrasound and machine learning algorithms

ML Gild, M Chan, J Gajera, B Lurie… - Clinical …, 2022 - Wiley Online Library
Abstract Background Indeterminate thyroid nodules (Bethesda III) are challenging to
characterize without diagnostic surgery. Auxiliary strategies including molecular analysis …

Molecular Diagnostics and [18F]FDG-PET/CT in Indeterminate Thyroid Nodules: Complementing Techniques or Waste of Valuable Resources?

EJ de Koster, H Morreau, GS Bleumink… - Thyroid, 2024 - liebertpub.com
Background: An accurate preoperative workup of cytologically indeterminate thyroid nodules
(ITN) may rule out malignancy and avoid diagnostic surgery for benign nodules. This study …

Prognostic value of preoperative molecular testing and implications for initial surgical management in thyroid nodules harboring suspected (Bethesda V) or known …

MA Schumm, ML Shu, EG Hughes… - … –head & neck …, 2023 - jamanetwork.com
Importance Molecular testing is commonly used in the diagnosis of thyroid nodules with
indeterminate cytology. The role of molecular testing in prognosticating oncologic outcomes …