In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Loss of function in tumor suppressor genes is commonly associated with the
onset/progression of cancer and treatment resistance. The p53 tumor suppressor gene, a …

The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …

Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD‐1) and
programmed death‐ligand 1 (PD‐L1) have improved the survival of patients with non‐small …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

The progression of cancers from primary tumors to invasive and metastatic stages accounts
for the overwhelming majority of cancer deaths. Understanding the molecular events which …

Purpose Mounting evidence suggests that tumor-infiltrating immune cells have prognostic
value for patients with solid organ malignancies. Our aim was to investigate the prognostic …

Activation of the translation initiation factor 4E (eIF4E) promotes malignant transformation
and metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by …

MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine
kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap …