Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
H Yu, H Lee, A Herrmann, R Buettner, R Jove - Nature reviews cancer, 2014 - nature.com
Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …
The role of miRNAs in ovarian cancer pathogenesis and therapeutic resistance–a focus on signaling pathways interplay
One of the most prevalent and lethal forms of gynecological cancer is ovarian cancer (OC),
which is often diagnosed in its latter, deadly stages. The OC's high mortality and …
which is often diagnosed in its latter, deadly stages. The OC's high mortality and …
Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications
K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes
DW Shen, LM Pouliot, MD Hall, MM Gottesman - Pharmacological reviews, 2012 - ASPET
Cisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness
seems to be due to the unique properties of cisplatin, which enters cells via multiple …
seems to be due to the unique properties of cisplatin, which enters cells via multiple …
MicroRNAs in development and disease
D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques
As being the most extensively studied, non-coding, evolutionary conserved, post-
transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention …
transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention …
Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
E Chirshev, KC Oberg, YJ Ioffe… - Clinical and translational …, 2019 - Springer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
Targeting microRNAs in cancer: rationale, strategies and challenges
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
The role of exosomes and miRNAs in drug‐resistance of cancer cells
DH Bach, JY Hong, HJ Park… - International journal of …, 2017 - Wiley Online Library
Chemotherapy, one of the principal approaches for cancer patients, plays a crucial role in
controlling tumor progression. Clinically, tumors reveal a satisfactory response following the …
controlling tumor progression. Clinically, tumors reveal a satisfactory response following the …