Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

In the post-genomic era, the goal of personalized medicine is to determine the correlation
between genotype and phenotype. Developing high-throughput genotyping technologies …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Protein ubiquitination and deubiquitination are central to the control of a large number of
cellular pathways and signaling networks in eukaryotes. Although the essential roles of …

Bone marrow injury remains a serious concern in traditional cancer treatment. Ferroptosis is
an iron-and oxidative-dependent form of regulated cell death that has become part of an …

Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone
marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater …

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ) is a transcription factor that
modulates many biological processes including cell differentiation, motility, growth arrest …

It is emerging that the pathways that process newly transcribed RNA molecules also
regulate the response to DNA damage at multiple levels. Here, we discuss recent insights …

Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in
check by networks of DNA repair factors that monitor the transcription process to repair DNA …