Parkinson's disease [PD] is the second most common neurodegenerative disorder after
Alzheimer's disease, affecting 1% of the population over the age of 55. The underlying …

Lower motor neuron degeneration is the pathological hallmark of spinal muscular atrophy
(SMA), a hereditary motor neuron disease caused by loss of the SMN1 gene and the …

Abstract Background Focal Axonal Swellings arise in several leading neurodegenerative
diseases of the central nervous system and are hallmark features of concussions and …

It was previously shown that activation of the processes of neurogenesis in the olfactory
epithelium (OE) can be caused after intranasal administration of toxic or neurotrophic …

The presence of diffuse Focal Axonal Swellings (FAS) is a hallmark cellular feature in many
neurological diseases and traumatic brain injury. Among other things, the FAS have a …

In the present study, for the first time, a thermodynamically consistent large deformation
theory is developed to model the multi physics problem of axonal swelling which is the …

Using a model for the dynamics of the full somatic nervous system of the nematode C.
elegans, we address how biological network architectures and their functionality are …

The accurate diagnosis and assessment of neurodegenerative disease and traumatic brain
injuries (TBI) remain open challenges. Both cause cognitive and functional deficits due to …

Computational modeling of the neural activity in the human spinal cord may help elucidate
the underlying mechanisms involved in the complex processing of painful stimuli. In this …

Volume transmission is a fundamental neural communication mechanism in which neurons
in one brain nucleus modulate the neurotransmitter concentration in the extracellular space …