Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …

Existing guidelines on the preparation (Planning Research and Experimental Procedures on
Animals: Recommendations for Excellence (PREPARE)) and reporting (Animal Research …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

Pancreatic ductal adenocarcinoma (PDAC) is among the dangerous human cancers, is the
10th highly prevalent cancer, and the fourth sole cause of cancer-related mortality in the …

Background: The tumor microenvironment (TME) is composed of fibro-inflammatory cells
and extracellular matrix (ECM) components. However, the exact contribution of the various …

In animal models of cancer, oncologic imaging has evolved from a simple assessment of
tumor location and size to sophisticated multimodality exploration of molecular, physiologic …

Cancer-associated cachexia (CAC) is a critical contributor to pancreatic ductal
adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to …

Abstract Background Cytosolic 5′-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic
nucleoside monophosphates to produce nucleosides and inorganic phosphates. Here, we …

Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A
ketogenic diet (KD), characterized by a very low carbohydrate and high fat composition, has …

Background & Aims Loss of AT-rich interactive domain-containing protein 1A (ARID1A)
fosters acinar-to-ductal metaplasia (ADM) and pancreatic carcinogenesis by down …