Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease

PM Ridker, M Rane - Circulation research, 2021 - Am Heart Assoc
IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …

COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease

D Tomasoni, L Italia, M Adamo… - European journal of …, 2020 - Wiley Online Library
Patients with cardiovascular disease and, namely, heart failure are more susceptible to
coronavirus disease 2019 (COVID‐19) and have a more severe clinical course once …

Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy

RM Inciardi, M Adamo, L Lupi, DS Cani… - European heart …, 2020 - academic.oup.com
Aims To compare demographic characteristics, clinical presentation, and outcomes of
patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia …

Iron deficiency and cardiovascular disease

G Savarese, S von Haehling, J Butler… - European heart …, 2023 - academic.oup.com
Iron deficiency (ID) is common in patients with cardiovascular disease. Up to 60% of patients
with coronary artery disease, and an even higher proportion of those with heart failure (HF) …

Inflammation in Heart Failure: JACC State-of-the-Art Review

SP Murphy, R Kakkar, CP McCarthy… - Journal of the American …, 2020 - jacc.org
It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …

[HTML][HTML] Heart failure with preserved ejection fraction: JACC scientific statement

BA Borlaug, K Sharma, SJ Shah, JE Ho - Journal of the American College …, 2023 - Elsevier
The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF)
continue to rise in tandem with the increasing age and burdens of obesity, sedentariness …

[HTML][HTML] COVID-19 and heart failure: from epidemiology during the pandemic to myocardial injury, myocarditis, and heart failure sequelae

L Italia, D Tomasoni, S Bisegna, E Pancaldi… - Frontiers in …, 2021 - frontiersin.org
A close and intriguing relationship has been suggested between heart failure (HF) and
coronavirus disease 2019 (COVID-19). First, COVID-19 pandemic represented a global …

[HTML][HTML] Iron deficiency in heart failure: mechanisms and pathophysiology

RIS Alnuwaysir, MF Hoes, DJ van Veldhuisen… - Journal of clinical …, 2021 - mdpi.com
Iron is an essential micronutrient for a myriad of physiological processes in the body beyond
erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure …

[HTML][HTML] Ferroptosis: the potential value target in atherosclerosis

S Ouyang, J You, C Zhi, P Li, X Lin, X Tan, W Ma… - Cell Death & …, 2021 - nature.com
In advanced atherosclerosis (AS), defective function-induced cell death leads to the
formation of the characteristic necrotic core and vulnerable plaque. The forms and …

[HTML][HTML] Interleukin-6: a novel target for cardio-cerebrovascular diseases

JH Su, MY Luo, N Liang, SX Gong, W Chen… - Frontiers in …, 2021 - frontiersin.org
Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and
cerebrovascular disease, being a serious threat to human health. A growing number of …