Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

The belief that the vertebrate brain functions normally without classical lymphatic drainage
vessels has been held for many decades. On the contrary, new findings show that functional …

NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …

Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences …

Background: An increasing number of studies suggest that diet plays an important role in
regulating aging processes and modulates the development of the most important age …

The impact of vascular risk factors on cognitive function has garnered much interest in recent
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …

Cerebrovascular endothelial cells (CECs) are integral components of both the blood‐brain
barrier (BBB) and the neurovascular unit (NVU). As the primary cell type of the BBB, CECs …

Glia, a non-excitable cell type once considered merely as the connective tissue between
neurons, is nowadays acknowledged for its essential contribution to multiple physiological …

Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …