Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Many biological programs are regulated at the transcriptional level. This is generally
achieved by the concerted actions of several transcription factors. Recent findings have …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Transcriptional complexes that contain peroxisome-proliferator-activated receptor
coactivator (PGC)-1α control mitochondrial oxidative function to maintain energy …

Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated
action of numerous transcription factors and associated coregulators. Several members of …

The dynamics of mitochondrial biogenesis and function is a complex interplay of cellular and
molecular processes that ultimately shape bioenergetics capacity. Mitochondrial mass, by …

This paper reviews the current understanding of the molecular basis of the peroxisome
proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α)–mediated pathway and …

The heart has a tremendous capacity for ATP generation, allowing it to function as an
efficient pump throughout the life of the organism. The adult myocardium uses either fatty …

Brain metastases are among the most feared complications in breast cancer, as no therapy
exists that prevents or eliminates breast cancer spreading to the brain. New therapeutic …

Chronic disruption of energy balance, where energy intake exceeds expenditure, is a major
risk factor for the development of metabolic syndrome. The latter is characterized by a …