Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …
antibodies. Recently, aptamers have garnered increased interest due to their unique …
[HTML][HTML] Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development
Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
Engineering synthetic RNA devices for cell control
The versatility of RNA in sensing and interacting with small molecules, proteins and other
nucleic acids while encoding genetic instructions for protein translation makes it a powerful …
nucleic acids while encoding genetic instructions for protein translation makes it a powerful …
Functional DNA molecules enable selective and stimuli-responsive nanoparticles for biomedical applications
Conspectus Nanoparticles (NPs) have enormous potential to improve disease diagnosis
and treatment due to their intrinsic electronic, optical, magnetic, mechanical, and …
and treatment due to their intrinsic electronic, optical, magnetic, mechanical, and …
Do aptamers always bind? The need for a multifaceted analytical approach when demonstrating binding affinity between aptamer and low molecular weight …
F Bottari, E Daems, AM de Vries… - Journal of the …, 2020 - ACS Publications
In this manuscript, we compare different analytical methodologies to validate or disprove the
binding capabilities of aptamer sequences. This was prompted by the lack of a universally …
binding capabilities of aptamer sequences. This was prompted by the lack of a universally …
Immobilization techniques for aptamers on gold electrodes for the electrochemical detection of proteins: a review
FV Oberhaus, D Frense, D Beckmann - Biosensors, 2020 - mdpi.com
The development of reliable biosensing platforms plays a key role in the detection of
proteins in clinically and environmentally derived samples for diagnostics, as well as for …
proteins in clinically and environmentally derived samples for diagnostics, as well as for …
Nucleic acid and peptide aptamers: fundamentals and bioanalytical aspects
In recent years new nucleic acid and protein‐based combinatorial molecules have attracted
the attention of researchers working in various areas of science, ranging from medicine to …
the attention of researchers working in various areas of science, ranging from medicine to …
Aptamer modules as sensors and detectors
Aptamers comprise a range of molecular recognition scaffolds that can be engineered to
bind to a legion of different proteins and other targets with excellent specificity and affinity …
bind to a legion of different proteins and other targets with excellent specificity and affinity …
Anything you can do, I can do better: Can aptamers replace antibodies in clinical diagnostic applications?
M Bauer, M Strom, DS Hammond, S Shigdar - Molecules, 2019 - mdpi.com
The mainstay of clinical diagnostics is the use of specialised ligands that can recognise
specific biomarkers relating to pathological changes. While protein antibodies have been …
specific biomarkers relating to pathological changes. While protein antibodies have been …
Analysis of in vitro aptamer selection parameters
Nucleic acid aptamers are novel molecular recognition tools that offer many advantages
compared to their antibody and peptide-based counterparts. However, challenges …
compared to their antibody and peptide-based counterparts. However, challenges …