Summary Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
polypeptide (GIP) are incretins that stimulate insulin secretion from pancreatic β cells in …

Simple Summary When we ingest a meal, our intestine secretes hormones that are released
into the bloodstream. Amongst these hormones are the incretins hormones which stimulate …

Glucagon-like peptide-1 (GLP-1) analogs are considered the best current medicines for type
2 diabetes (T2D) and obesity due to their actions in lowering blood glucose and body …

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
potentiate glucose-induced insulin secretion and are therefore thought to be responsible for …

Aims/hypothesis In adult human islets, insulin and glucagon production is largely restricted
to individual cell populations. The production of these hormones is less segregated during …

The prevalence of obesity continues to grow rapidly worldwide, posing many public health
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …

Generation of surrogate sources of insulin-producing β-cells remains a goal of diabetes
therapy. While most efforts have been directed at differentiating embryonic or induced …

Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone
secreted postprandially from enteroendocrine K cells, but despite therapeutically interesting …

Peptide hormones are first produced as larger precursor prohormones that require
endoproteolytic cleavage to liberate the mature hormones. A structurally conserved but …

Background and Purpose Glucose‐dependent insulinotropic polypeptide (GIP) affects lipid,
bone and glucose homeostasis. High‐affinity ligands for the GIP receptor are needed to …