Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …

Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ
multiple mechanisms to avoid immune recognition and suppress antitumor immune …

Background COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from
asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are …

Objectives Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the
interplay between both genetic and epigenetic factors. Monocytes are crucial players of the …

Glucocorticoids (GCs) exert potent anti-inflammatory effects in immune cells through the
glucocorticoid receptor (GR). Dendritic cells (DCs), central actors for coordinating immune …

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most common
focal epilepsy in adults. It is characterized by alarming rates of pharmacoresistance …

Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin
tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA …

JCI Insight - The synovial and blood monocyte DNA methylomes mirror prognosis, evolution,
and treatment in early arthritis Go to The Journal of Clinical Investigation About Editors …

Background Giant cell arteritis (GCA) is an immune-mediated large-vessels vasculitis with
complex etiology. Although the pathogenic mechanisms remain poorly understood, a central …

Umbilical and placental vessels and endothelial cells (EC) are common models to study
placental function and vascular programming. Arterio-venous differences are present in the …