Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

Mitochondria are essential cellular organelles that are involved in regulating cellular energy,
metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic …

ABSTRACT Introduction Von Hippel-Lindau (VHL) disease is an inherited autosomal
dominant syndrome caused by a germline mutation and/or deletion of the VHL gene …

Renal cell carcinoma (RCC) records for 2% of all cancer assessments and mortality
worldwide, and its severity has more than doubled in the world over the last half-century …

Non-clear cell renal cell carcinoma (nccRCC) is a heterogeneous group of malignancies
that represents 25% of renal cell carcinoma (RCC) cases. Treatment for non-clear cell …

Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy with high
mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective …

Aim Non-clear cell renal cell carcinoma (nccRCC) tumours include a heterogeneous group
of malignancies that profoundly differ in terms of morphology, genetic profile, clinical …

Abstract In the United States, the lifetime risk of a cancer diagnosis is nearly 40%; in 2016,
that represents almost 1.6 million new patients, and despite advances in early diagnosis and …

The anti-cancer properties of curcumin in vitro have been documented. However, its clinical
use is limited due to rapid metabolization. Since irradiation of curcumin has been found to …