Pathogenicity and virulence of Mycobacterium leprae

M Sugawara-Mikami, K Tanigawa, A Kawashima… - Virulence, 2022 - Taylor & Francis
Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …

Regulatory T-cells at the interface between human host and pathogens in infectious diseases and vaccination

MC Boer, SA Joosten, THM Ottenhoff - Frontiers in immunology, 2015 - frontiersin.org
Regulatory T-cells (Tregs) act at the interface of host and pathogen interactions in human
infectious diseases. Tregs are induced by a wide range of pathogens, but distinct effects of …

The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy

ABL Fonseca, MV Simon, RA Cazzaniga… - Infectious diseases of …, 2017 - Springer
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. According to
official reports from 121 countries across five WHO regions, there were 213 899 newly …

Differential expression of programmed death 1 (PD-1) on various immune cells and its role in human leprosy

M Tarique, H Naz, M Suhail, A Turan, C Saini… - Frontiers in …, 2023 - frontiersin.org
Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Leprosy patients
have been found to have defects in T cells activation, which is critical to the clearance of the …

Immunology of leprosy

LAR Froes Jr, MAB Trindade… - International Reviews of …, 2022 - Taylor & Francis
Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical
manifestations, which are strongly correlated with the host's immune response. Skin lesions …

Immunology of leprosy and diagnostic challenges

I Nath, C Saini, VL Valluri - Clinics in Dermatology, 2015 - Elsevier
Leprosy, caused by noncultivable Mycobacterium leprae (ML), has varied manifestations,
which are associated with the host immune responses. The dermal involvement is …

Reciprocity between regulatory T cells and Th17 cells: relevance to polarized immunity in leprosy

S Sadhu, BK Khaitan, B Joshi, U Sengupta… - PLoS neglected …, 2016 - journals.plos.org
T cell defect is a common feature in lepromatous or borderline lepromatous leprosy (LL/BL)
patients in contrast to tuberculoid or borderline tuberculoid type (TT/BT) patients …

T-cell regulation in lepromatous leprosy

K Bobosha, L Wilson, KE van Meijgaarden… - PLoS neglected …, 2014 - journals.plos.org
Regulatory T (Treg) cells are known for their role in maintaining self-tolerance and balancing
immune reactions in autoimmune diseases and chronic infections. However, regulatory …

Susceptibility and resistance in leprosy: Studies in the mouse model

LB Adams - Immunological Reviews, 2021 - Wiley Online Library
Leprosy is a chronic granulomatous infectious disease caused by the pathogen,
Mycobacterium leprae, and the more recently discovered, M. lepromatosis. Described in …

Diet and nutrition: An important risk factor in leprosy

VP Dwivedi, A Banerjee, I Das, A Saha, M Dutta… - Microbial …, 2019 - Elsevier
Leprosy, once considered as poor man's disease may cause severe neurological
complications and physical disabilities. Classification of leprosy depends upon the cell …