The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and
possesses unique characteristics that make the delivery of drugs to the brain a great …

Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor
for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate …

Effective delivery of protein therapeutics to the central nervous system (CNS) has been
greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB …

Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Over the last decades, considerable efforts have been put into developing active nanocarrier
systems that cross the blood brain barrier (BBB) to treat brain-related diseases such as …