Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

Oxidative stress (OS) is defined as a disturbance in the prooxidant‐antioxidant balance of
the cell, in favor of the former, which results in the antioxidant capacity of the cell to be …

Recent clinical trials have shown that sodium glucose co-transport 2 (SGLT2) inhibitors have
dramatic beneficial cardiovascular outcomes. These include a reduced incidence of …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Background: Although empagliflozin was shown to profoundly reduce cardiovascular events
in diabetic patients and blunt the decline in cardiac function in nondiabetic mice with …

Low-grade persistent inflammation is a feature of diabetes-driven vascular complications, in
particular activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) …

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are new oral drugs for the therapy of
patients with type 2 diabetes mellitus (T2DM). Research in the past decade has shown that …

Abstract Background Type 2 diabetes (T2D) is associated with generalized vascular
dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and …

Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …