Natural products and their molecular frameworks have a long tradition as valuable starting
points for medicinal chemistry and drug discovery. Recently, there has been a revitalization …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

There is mounting urgency to find new drugs for the treatment of serious infectious diseases
and cancer that are rapidly developing resistance to previously effective drugs. One …

Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

Covering: up to 2020 Natural products have a long history in drug discovery, with their
inherent biological activity often tailored by medicinal chemists to arrive at the final drug …

Covering: 2013–2022. Chemical diversification of natural products is an efficient way to
generate natural product-like compounds for modern drug discovery programs. Utilizing ring …

Many nitrogen-moiety containing alkaloids derived from plant origins are bioactive and play
a significant role in human health and emerging medicine. Noscapine, a …

Computer-aided research on the relationship between molecular structures of natural
compounds (NC) and their biological activities have been carried out extensively because …

Among the range of P, N-chelating ligands that have been employed in asymmetric
catalysis, those relying on atropisomerism for the stability of individual enantiomers form a …

Inflammatory processes occur as a generic response of the immune system and can be
triggered by various factors, such as infection with pathogenic microorganisms or damaged …