The plasticity of pancreatic cancer stem cells: Implications in therapeutic resistance

K Patil, FB Khan, S Akhtar, A Ahmad… - Cancer and Metastasis …, 2021 - Springer
The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a
hardwired defined entity has evolved our understanding of the functional and biological …

Understanding the molecular mechanisms that regulate pancreatic cancer stem cell formation, stemness and chemoresistance: a brief overview

GP Nagaraju, B Farran, T Luong… - Seminars in Cancer …, 2023 - Elsevier
Pancreatic cancer is one of the most aggressive cancers worldwide due to the resistances to
conventional therapies and early metastasis. Recent research has shown that cancer stem …

Metabolic rewiring and stemness: a critical attribute of pancreatic cancer progression

AO Ogunleye, RK Nimmakayala, SK Batra… - Stem Cells, 2023 - academic.oup.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases with a
poor 5-year survival rate. PDAC cells rely on various metabolic pathways to fuel their …

Cancer stem cells in pancreatic ductal adenocarcinoma

R Bubin, R Uljanovs, I Strumfa - International Journal of Molecular …, 2023 - mdpi.com
The first discovery of cancer stem cells (CSCs) in leukaemia triggered active research on
stemness in neoplastic tissues. CSCs represent a subpopulation of malignant cells, defined …

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists

I Garajová, M Peroni, F Gelsomino, F Leonardi - Current Oncology, 2023 - mdpi.com
Pancreatic cancer (PDAC) is one of the most aggressive solid tumors and is showing
increasing incidence. The aim of our review is to provide practical help for all clinical …

Next generation of cancer drug repurposing: therapeutic combination of aspirin and oseltamivir phosphate potentiates gemcitabine to disable key survival pathways …

B Qorri, RB Mokhtari, WW Harless, MR Szewczuk - Cancers, 2022 - mdpi.com
Simple Summary Drug repurposing in combination with clinical standard chemotherapeutics
opens a novel and promising clinical treatment approach for patients with pancreatic cancer …

Histone modifications represent a key epigenetic feature of epithelial-to-mesenchyme transition in pancreatic cancer

Y Xu, Q Zhu - International Journal of Molecular Sciences, 2023 - mdpi.com
Pancreatic cancer is one of the most lethal malignant diseases due to its high invasiveness,
early metastatic properties, rapid disease progression, and typically late diagnosis. Notably …

The Link between Diabetes, Pancreatic Tumors, and miRNAs—New Players for Diagnosis and Therapy?

M Kozłowska, A Śliwińska - International Journal of Molecular Sciences, 2023 - mdpi.com
Despite significant progress in medicine, pancreatic cancer is one of the most tardily
diagnosed cancer and is consequently associated with a poor prognosis and a low survival …

Umbelliprenin induces autophagy and apoptosis while inhibits cancer cell stemness in pancreatic cancer cells

H Wang, Y Liu, Y Wang, T Xu, G Xia… - Cancer Medicine, 2023 - Wiley Online Library
Background Umbelliprenin is a sesquiterpene coumarin isolated from Artemisia absinthium
L. and shows antitumor effects in various cancers by inducing apoptosis. However, the …

Gold Nanoparticles Synthesized by an Aqueous Extract of Codium tomentosum as Potential Antitumoral Enhancers of Gemcitabine

N González-Ballesteros, I Maietta, R Rey-Méndez… - Marine Drugs, 2022 - mdpi.com
Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the
available chemotherapeutic drugs, whose side effects, it must also be noted, still raise …