Members of the multiple antibiotic resistance regulator (MarR) family of transcription factors
are critical for bacterial cells to respond to chemical signals and to convert such signals into …

Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways.
Such regulatory circuits ensure that anabolic pathways remain repressed unless final …

While the nutrient limited fed-batch technology is the standard of the cultivation of
microorganisms and production of heterologous proteins in industry, despite its advantages …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines
are one of the most successful and cost-effective tools for disease prevention. One of the key …

Neisseria meningitidis and Neisseria gonorrhoeae are two obligate human pathogens that
have evolved to be uniquely adapted to their host. The meningococcus is frequently carried …

MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that
regulate transcription in response to a wide range of chemical signals. Although specific …

We present a novel system that leverages curators in the loop to develop a dataset and
model for detecting structure features and functional annotations at residue-level from …

Multiple antibiotic resistance regulator (MarR) family proteins are widely conserved
transcription factors that control bacterial resistance to antibiotics, environmental stresses, as …

In silico studies are attracting considerable interest due to their ability to understand protein–
ligand interactions at the atomic level. The main principal tools of this in silico analyses are …