The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Temperature is a critical—yet sometimes overlooked—parameter in microfluidics.
Microfluidic devices can experience heating inside their channels during operation due to …

Comprehensive electrophysiological characterizations of human induced pluripotent stem
cell (hiPSC)-derived neuronal networks are essential to determine to what extent these in …

Objective. The purpose of this study is to investigate whether and how the balance between
excitation and inhibition ('E/I balance') influences the spontaneous development of human …

Paper-based cultures are an emerging platform for preparing 3D tissue-like structures.
Chemical gradients can be imposed upon these cultures, generating microenvironments …

Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic
proteins. While much has been learned on synaptic protein synthesis, little is known on the …

We designed a miniaturized and thin polydimethylsiloxane (PDMS) microchannel device
compatible with commercial microelectrode array (MEA) chips. It was optimized for selective …

Synaptic integrity and function depend on myriad proteins-labile molecules with finite
lifetimes that need to be continually replaced with freshly synthesized copies. Here we …

Advances in primary and stem cell derived neuronal cell culture techniques and abundance
of available neuronal cell types have enabled in vitro neuroscience as a substantial …

A physiologically relevant environment is essential for successful long-term cell culturing in
vitro. Precise control of temperature, one of the most crucial environmental parameters in …