Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations
identified in human cancer about 3 decades ago. Studies during the last quarter century …

Esophageal squamous-cell carcinoma (ESCC) is an invasive neoplastic disease generally
associated with poor survival rates. The incidence of ESCC is characterized by marked …

Targeted Therapies in Gynecologic Cancers Page 1 Current Cancer Drug Targets, 2006, 6,
333-363 333 1568-0096/06 $50.00+.00 © 2006 Bentham Science Publishers Ltd. Targeted …

Cervical cancer is one of the most common gynecological cancers worldwide. Over the past
decade, much progress has been made in understanding the genetic changes associated …

Papillomaviruses are small, non-enveloped, epitheliotropic, double-stranded DNA viruses
that infect mucosal and cutaneous epithelia in a wide variety of higher vertebrates in a …

Introduction: A high incidence of K-Ras mutations has been identified in a variety of human
cancers, especially in codon 12, 13, and 61. Nevertheless, the presence of K-Ras mutations …

Conventional methods for point mutation detection are usually multi-stage, laborious, and
need to use radioactive isotopes or other hazardous materials, and the assay results are …

OBJECTIVE.: The objective of this study was to investigate whether the expression of SKP2,
p27 and phospho-MAPK/ERK1/2 is associated with the progression of human cervical …

Background: Human papillomavirus (HPV) in childhood causes skin and anogenital warts
as well as the recurrent respiratory papillomatosis, a life-threatening cause of upper airway …

Aberrant activation of GTP ases is common in cervical cancer, and their proper biological
functions largely depend on a post‐translational modification termed prenylation …