Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Cancer cells have defects in regulatory mechanisms that usually control cell proliferation
and homeostasis. Different cancer cells share crucial alterations in cell physiology, which …

Although the growth factor progranulin was discovered more than two decades ago, the
functional receptor remains elusive. Here, we discovered that EphA2, a member of the large …

Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a
secreted growth factor that implicates in a multitude of processes ranging from regulation of …

Prostate cancer (PCa) development and progression relies on the programming of glucose
and lipid metabolism, and this involves alterations in androgen receptor expression and …

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its
expression and impact in human tumors is unclear. In this study, sortilin was analyzed by …

High aggressiveness is a hallmark of glioblastoma and predicts poor prognosis of patients
with glioblastoma. The expression level of sortilin has been preliminarily reported to be …

Neurotrophin receptors are emerging targets in oncology, but their clinicopathologic
significance in thyroid cancer is unclear. In this study, the neurotrophin tyrosine receptor …

Progranulin is a growth factor with pro-tumorigenic activity. We recently demonstrated that in
mesothelioma, progranulin regulates cell migration, invasion, adhesion, and in vivo tumor …

Background: The scientific interest regarding the involvement of peptides in cancer has
increased in the last few years. In tumor cells, the overexpression of peptides and their …