Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …

ABSTRACT MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme
CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a …

Highlights•CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune
cells.•CD73 has been hijacked by TME to promote tumor growth and metastasis.•Targeting …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

CD73 generation of immunosuppressive adenosine within the hypoxic tumor
microenvironment causes dysregulation of immune cell infiltrates, resulting in tumor …

The ability of focal radiotherapy to promote priming of tumor-specific CD8+ T cells and
increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3 …

Within the past 10 years the field of signaling via extracellular nucleotides has witnessed a
breath-taking expansion. Molecular cloning of receptors and physiological and …