Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Although flavin-dependent halogenases (FDHs) are attractive for C–H bond activation, their
applications are limited due to low turnover and stability. We have previously shown that …

Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …

The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …

Covering: up to the end of May 2012 Riboflavin-based coenzymes, tightly bound to enzymes
catalyzing substrate oxidations and reductions, enable an enormous range of chemical …

Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds
continues to progress at a rapid pace due to the significant economic and environmental …

Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …