Glycobiology: Toward Understanding the Function of Sugars | Chemical Reviews ACS ACS
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The TIM (T cell/transmembrane, immunoglobulin, and mucin) gene family plays a critical role
in regulating immune responses, including allergy, asthma, transplant tolerance …

We have developed TM-align, a new algorithm to identify the best structural alignment
between protein pairs that combines the TM-score rotation matrix and Dynamic …

Bivalent and bispecific antibodies and their fragments have immense potential for practical
application. Here we describe the design of small antibody fragments with two antigen …

Almost all of the key molecules involved in the innate and adaptive immune response are
glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding …

Most proteins for structural biology studies are produced by high-level expression in
Escherichia coli. However, prokaryotic based expression systems fail to generate correctly …

Since the first crystal structure of an immunoglobulin revealed a modular architecture, the
characteristic β-sheet fold of the immunoglobulin domain has been found in many other …

Apert syndrome is a distinctive human malformation comprising craniosynostosis and
severe syndactyly of the hands and feet. We have identified specific missense substitutions …

We have determined the 2.0 Å crystal structure of a fragment of human fibronectin
encompassing the seventh through the RGD-containing tenth type III repeats (FN7–10). The …

Abstract Three‐dimensional (3D) domain swapping creates a bond between two or more
protein molecules as they exchange their identical domains. Since the term'3D domain …