Presentation of antigenic peptides by MHC class II molecules to CD4+ T cells requires many
events in both the biosynthetic and endocytic pathways that must all occur in a controlled …

Despite the continuous exposure to a wide variety of pathogenic microbes, vertebrate
organisms usually do not succumb to infections. This ability to withstand these challenges is …

Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to
have been described, and it has emerged recently to be an important regulator of innate and …

The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but
the signaling mechanism is not evident. We hypothesized that signaling requires an …

Recent data suggest that survival of resting, naïve T cells requires an interaction with self
MHC molecules. From analysis of the class I MHC-restricted T cell receptor transgenic strain …

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is overexpressed
in prostate cancer, but the mechanism by which MIF exerts effects on tumor cells remains …

Although the thymus produces many immature thymocytes, few of these cells mature.
Positive selection has been thought to limit thymocyte development. In thymuses expressing …

αβ T cell receptor (TCR) V (D) J genes code for billions of TCR combinations. However, only
some appear on peripheral T cells in any individual because, to mature, thymocytes must …

Macrophage migration inhibitory factor (MIF) is a 12.5 kD polypeptide that serves as a critical
regulator of cell functions such as gene expression, proliferation or apoptosis. However, the …

We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto
major histocompatibility complex class II molecules. A b molecules in these mice matured …