Early life exposure to per-and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of …

BE Blake, SE Fenton - Toxicology, 2020 - Elsevier
Per-and polyfluoroalkyl substances (PFAS) are ubiquitous drinking water contaminants of
concern due to mounting evidence implicating adverse health outcomes associated with …

[HTML][HTML] Oxidative stress in placental pathology

MH Schoots, SJ Gordijn, SA Scherjon, H van Goor… - Placenta, 2018 - Elsevier
The most important function of the placenta is the exchange of nutrients and oxygen
between a mother and her fetus. To establish a healthy functioning placenta, placentation …

[HTML][HTML] Oxidative stress: Normal pregnancy versus preeclampsia

DI Chiarello, C Abad, D Rojas, F Toledo… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies

A Umapathy, LW Chamley, JL James - Angiogenesis, 2020 - Springer
A branched vascular network is crucial to placental development and is dependent on
factors such as vascular endothelial growth factor (VEGF), placental growth factor (PlGF) …

Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development

F Soncin, M Khater, C To, D Pizzo, O Farah… - …, 2018 - journals.biologists.com
An increasing body of evidence points to significant spatio-temporal differences in early
placental development between mouse and human, but a detailed comparison of placentae …

Circulating exosomal miRNA profile during term and preterm birth pregnancies: a longitudinal study

R Menon, C Debnath, A Lai, D Guanzon… - …, 2019 - academic.oup.com
Despite decades of research in the field of human reproduction, the mechanisms
responsible for human parturition still remain elusive. The objective of this study was to …

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy

JJ Fisher, LA Bartho, AV Perkins… - Clinical and …, 2020 - Wiley Online Library
Mitochondria are central to cell function. The placenta forms the interface between maternal
and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy …

Extracellular vesicles-crucial players in human pregnancy

N Paul, Z Sultana, JJ Fisher, K Maiti, R Smith - Placenta, 2023 - Elsevier
Extracellular vesicles (EVs) are lipid-bilayer enclosed membrane vesicles released by cells
in physiological and pathological states. EVs are generated and released through a variety …

Selenoproteins in the human placenta: how essential is selenium to a healthy start to life?

C Hogan, AV Perkins - Nutrients, 2022 - mdpi.com
Selenium is an essential trace element required for human health, and selenium deficiency
has been associated with many diseases. The daily recommended intake of selenium is 60 …

Preeclampsia link to gestational hypoxia

W Tong, DA Giussani - Journal of developmental origins of health …, 2019 - cambridge.org
Complications of pregnancy remain key drivers of morbidity and mortality, affecting the
health of both the mother and her offspring in the short and long term. There is lack of …