Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Background This study aimed to investigate the effect of bone marrow mesenchymal stem
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

OBJECTIVE: During the development of disease-modifying osteoarthritis (OA) drugs, rat
models of OA are frequently used for a first assessment of in vivo efficacy. The most …

Background Many patients report symptomatic relief after undergoing arthroscopy of the
knee for osteoarthritis, but it is unclear how the procedure achieves this result. We …

There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of
individuals worldwide. New treatment approaches require an understanding of the …

Knee osteoarthritis remains a tremendous public health concern, both in terms of health‐
related quality of life and financial burden of disease. Translational research is a critical step …

A major symptom of patients with osteoarthritis (OA) is pain that is triggered by peripheral as
well as central changes within the pain pathways. The current treatments for OA pain such …