The introduction of hyperpolarized gases (3He and 129Xe) has opened the door to
applications for which gaseous agents are uniquely suited—lung MRI. One of the pulmonary …

RATIONALE AND OBJECTIVES: Hyperpolarized gases such as 129Xe and 3He have high
potential as imaging agents for functional lung magnetic resonance imaging (MRI). We …

Background Fluorine-enhanced MRI is a relatively inexpensive and straightforward
technique that facilitates regional assessments of pulmonary ventilation. In this report, we …

Recent advances in imaging offer exciting opportunities to develop and validate lung-
specific biomarkers as valuable adjuncts to diagnosis, tests of treatment efficacy, and/or …

5 Srinivasan S, Doty SM, White TR, et al. Frequency, causes and outcome of home ventilator
failure. Chest 1998; 114: 1363–7. 6 Farré R, Navajas D, Prats E, et al. Performance of …

Purpose To investigate short‐and long‐time‐scale 3He diffusion in asthma. Materials and
Methods A hybrid MRI sequence was developed to obtain coregistered short‐and long‐time …

We report measurements of free diffusivity D0 and relaxation times T1 and T2 for pure C2F6
and C3F8 and their mixtures with oxygen. A simplified relaxation theory is presented and …

Lung imaging using conventional 1H MRI presents great challenges because of the low
density of lung tissue, lung motion and very fast lung tissue transverse relaxation (typical T2 …

Purpose To evaluate the effects of lung volume differences on apparent diffusion coefficient
(ADC) measurements on a regional basis, with breath holds at volumes adjusted for …

Despite a long history of development, diagnostic tools for in vivo regional assessment of
lungs in patients with pulmonary emphysema are not yet readily available. Recently, a new …