The COVID-19 pandemic is an extraordinary global emergency that has led to the
implementation of unprecedented measures in order to stem the spread of the infection …

“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Background Engaging in physical activity (PA) and avoiding sedentary behavior (SB) are
important for healthy ageing with benefits including the mitigation of disability and mortality …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

The remarkable success of cancer immunotherapies has provided new hope to cancer
patients. Unfortunately, a significant proportion of patients remain unable to respond to …

Introduction Increased mortality has been demonstrated in older adults with coronavirus
disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi …

Undertaking a high volume of physical activity is associated with reduced risk of a broad
range of clinically diagnosed cancers. These findings, which imply that physical activity …

Neutrophil dysfunction is a common feature of aging, and is associated with the
pathogenesis of many age-related diseases, including type 2 diabetes mellitus (T2DM) …

There is strong evidence that physical activity (PA) reduces risk, recurrence, and mortality
from breast cancer. Emerging data suggest that PA induces changes in inflammatory and …

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting
predominantly older adults. CLL is characterized by low physical fitness, reduced immunity …