In vitro models of traumatic brain injury

B Morrison III, BS Elkin, JP Dollé… - Annual review of …, 2011 - annualreviews.org
In vitro models of traumatic brain injury (TBI) are helping elucidate the pathobiological
mechanisms responsible for dysfunction and delayed cell death after mechanical stimulation …

Mathematical models of blast-induced TBI: current status, challenges, and prospects

RK Gupta, A Przekwas - Frontiers in neurology, 2013 - frontiersin.org
Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military
activities and is the leading cause of death and long-term disability among US soldiers. The …

Vagus nerve stimulation and other neuromodulation methods for treatment of traumatic brain injury

D Neren, MD Johnson, W Legon, SP Bachour, G Ling… - Neurocritical care, 2016 - Springer
The objective of this paper is to review the current literature regarding the use of vagus
nerve stimulation (VNS) in preclinical models of traumatic brain injury (TBI) as well as …

Stretch and/or oxygen glucose deprivation (OGD) in an in vitro traumatic brain injury (TBI) model induces calcium alteration and inflammatory cascade

E Salvador, M Burek, CY Förster - Frontiers in cellular neuroscience, 2015 - frontiersin.org
The blood-brain barrier (BBB), made up of endothelial cells of capillaries in the brain,
maintains the microenvironment of the central nervous system. During ischemia and …

Therapeutic potential of melatonin in traumatic central nervous system injury

S Samantaray, A Das, NP Thakore… - Journal of pineal …, 2009 - Wiley Online Library
A vast literature extolling the benefits of melatonin has accumulated during the past four
decades. Melatonin was previously considered of importance to seasonal reproduction and …

Models of traumatic cerebellar injury

MB Potts, H Adwanikar, LJ Noble-Haeusslein - The Cerebellum, 2009 - Springer
Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. Studies of
human TBI demonstrate that the cerebellum is sometimes affected even when the initial …

Potential roles of vagus nerve stimulation on traumatic brain injury: Evidence from in vivo and clinical studies

C Srihagulang, J Vongsfak, T Vaniyapong… - Experimental …, 2022 - Elsevier
Abstract Traumatic Brain Injury (TBI) is a one of the leading causes of death and disability
worldwide. The consequences of TBI can be divided into two stages: 1) the immediate …

In Vitro Models as a Platform to Investigate Traumatic Brain Injury

A Kumaria - Alternatives to Laboratory Animals, 2017 - journals.sagepub.com
Traumatic Brain Injury (TBI) remains a significant cause of mortality and morbidity, affecting
individuals of all age groups. Much remains to be learned about its complex …

Mimicking oxygen delivery and waste removal functions of blood

H Zhang, JE Barralet - Advanced Drug Delivery Reviews, 2017 - Elsevier
In addition to immunological and wound healing cell and platelet delivery, ion stasis and
nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes …

A microfluidic neuronal platform for neuron axotomy and controlled regenerative studies

Z Tong, M Segura-Feliu, O Seira, A Homs-Corbera… - RSC …, 2015 - pubs.rsc.org
Understanding the basic mechanisms of neural regeneration after injury is a pre-requisite for
developing appropriate treatments. Traditional approaches to model axonal lesions, such as …