Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

Substance use disorders are a global health problem with increasing prevalence resulting in
significant socioeconomic burden and increased mortality. Converging lines of evidence …

Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While
evidence suggests that adolescent alcohol use affects frontal brain regions that are …

Binge drinking during adolescence can have behavioral and neurobiological
consequences. We have previously found that adolescent intermittent ethanol (AIE) …

Adolescence is a critical period for brain maturation in which this organ undergoes critical
plasticity mechanisms that increase its vulnerability to the effects of alcohol. Significantly …

Adolescence involves significant reorganization within the medial prefrontal cortex (mPFC),
including modifications to inhibitory neurotransmission mediated through parvalbumin (PV) …

Adolescence is an important phase for the structural and functional development of the
brain. The immaturity of adolescent brain development is associated with high susceptibility …

Adolescent intermittent ethanol (AIE) exposure in rats leads to social deficits. Parvalbumin
(PV) expressing interneurons in the prelimbic cortex (PrL) contribute to social behavior, and …

Alcohol use during adolescence coincides with elevated risks of stress-related impairment in
adults, particularly via disrupted developmental trajectories of vulnerable corticolimbic and …

Adolescents often report consuming alcohol in large quantities, and binge drink with greater
frequency than adults. These age differences in alcohol consumption are largely …