3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

A characteristic of integrins is their ability to transfer chemical and mechanical signals across
the plasma membrane. Force generated by myosin II makes cells able to sense substrate …

Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally
diverse group of RNA binding proteins implicated in various functions in metazoans. Here …

Like the ancient Greek hero Hercules, striated muscle is famous for performing impressive
feats of strength. The procurement of food, breathing, and defense or escape from harm all …

Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more
than 15 proteins. Biochemical and structural analyses have contributed to detailed …

Polypyrimdine tract binding protein (PTB) is a regulator of alternative splicing, mRNA 3′
end formation, mRNA stability and localization, and IRES-mediated translation. Transient …

The RNA-binding protein IGF2BP1 (IGF-II mRNA binding protein 1) stabilizes the c-myc RNA
by associating with the Coding Region instability Determinant (CRD). If and how other …

Chicken embryo fibroblasts (CEFs) localize β-actin mRNA to their lamellae, a process
important for the maintenance of cell polarity and motility. The localization of β-actin mRNA …

Polypyrimidine tract‐binding protein (PTB), as a member of the heterogeneous nuclear
ribonucleoprotein family, functions by rapidly shuttling between the nucleus and the …