Fundamentals and methods for T‐and B‐cell epitope prediction
JL Sanchez-Trincado… - Journal of …, 2017 - Wiley Online Library
Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
developing pathogen‐specific memory that confers immunological protection. Memory and …
developing pathogen‐specific memory that confers immunological protection. Memory and …
In silico clinical trials: concepts and early adoptions
Innovations in information and communication technology infuse all branches of science,
including life sciences. Nevertheless, healthcare is historically slow in adopting …
including life sciences. Nevertheless, healthcare is historically slow in adopting …
Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
SARS-CoV-2 causes a severe respiratory disease called COVID-19. Currently, global health
is facing its devastating outbreak. However, there is no vaccine available against this virus …
is facing its devastating outbreak. However, there is no vaccine available against this virus …
[HTML][HTML] Preclinical and clinical development of neoantigen vaccines
L Li, SP Goedegebuure, WE Gillanders - Annals of Oncology, 2017 - Elsevier
Cancer neoantigens are antigens that result from somatic mutations present in individual
cancers. Neoantigens are considered important targets for cancer immunotherapy because …
cancers. Neoantigens are considered important targets for cancer immunotherapy because …
Low mutation burden in ovarian cancer may limit the utility of neoantigen-targeted vaccines
Due to advances in sequencing technology, somatically mutated cancer antigens, or
neoantigens, are now readily identifiable and have become compelling targets for …
neoantigens, are now readily identifiable and have become compelling targets for …
Antigenic peptide prediction from E6 and E7 oncoproteins of HPV types 16 and 18 for therapeutic vaccine design using immunoinformatics and MD simulation …
Human papillomavirus (HPV) induced cervical cancer is the second most common cause of
death, after breast cancer, in females. Three prophylactic vaccines by Merck Sharp & Dohme …
death, after breast cancer, in females. Three prophylactic vaccines by Merck Sharp & Dohme …
mRNA-based vaccine designing against Epstein-Barr virus to induce an immune response using immunoinformatic and molecular modelling approaches
Epstein-Barr Virus (EBV) is a human pathogen that has a morbidity rate of 90% in adults
worldwide. Infectious mononucleosis is caused by EBV replication in B cells and epithelial …
worldwide. Infectious mononucleosis is caused by EBV replication in B cells and epithelial …
The use of databases, data mining and immunoinformatics in vaccinology: where are we?
NR Hegde, S Gauthami… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Vaccinology has evolved from a sub-discipline focussed on simplistic vaccine
development based on antibody-mediated protection to a separate discipline involving …
development based on antibody-mediated protection to a separate discipline involving …
Building proteomic tool boxes to monitor MHC class I and class II peptides
FR Schumacher, L Delamarre, S Jhunjhunwala… - …, 2017 - Wiley Online Library
Major histocompatibility complex Class I (MHCI) and Class II (MHCII) presented peptides
powerfully modulate T cell immunity and play a vital role in generating effective anti‐tumor …
powerfully modulate T cell immunity and play a vital role in generating effective anti‐tumor …
Multi-epitope DnaK peptide vaccine against S. Typhi: an in silico approach
Salmonella is one of the key global causes of food and water borne enteric infections,
responsible for significant morbidity and mortality worldwide especially in developing …
responsible for significant morbidity and mortality worldwide especially in developing …