Regulation of neuronal RNA signatures by ELAV/Hu proteins

V Hilgers - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
The RNA‐binding proteins encoded by the highly conserved elav/Hu gene family, found in
all metazoans, regulate the expression of a wide range of genes, at both the co …

Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa

MG Llorente, ER Jones, A Eriksson, V Siska, KW Arthur… - Science, 2015 - science.org
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing
the evolutionary history of anatomically modern humans. However, historic migrations from …

Roles of embryonic lethal abnormal vision-like RNA binding proteins in cancer and beyond

H Cai, D Zheng, Y Yao, L Yang, X Huang… - Frontiers in Cell and …, 2022 - frontiersin.org
Embryonic lethal abnormal vision-like (ELAVL) proteins are RNA binding proteins that were
originally discovered as indispensable regulators of the development and functioning of the …

[HTML][HTML] ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system

K Oktaba, W Zhang, TS Lotz, DJ Jun, SB Lemke, SP Ng… - Molecular cell, 2015 - cell.com
Alternative polyadenylation (APA) has been implicated in a variety of developmental and
disease processes. A particularly dramatic form of APA occurs in the developing nervous …

MicroRNA-encoded behavior in Drosophila

J Picao-Osorio, J Johnston, M Landgraf, J Berni… - Science, 2015 - science.org
The relationship between microRNA (miRNA) regulation and the specification of behavior is
only beginning to be explored. We found that mutation of a single miRNA locus (miR …

Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory

P Ustaoglu, JK Gill, N Doubovetzky… - Communications …, 2021 - nature.com
Abstract Changes in gene expression are a hallmark of learning and memory consolidation.
Little is known about how alternative mRNA processing, particularly abundant in neuron …

Concentration and localization of coexpressed ELAV/Hu proteins control specificity of mRNA processing

E Zaharieva, IU Haussmann, U Bräuer… - Molecular and cellular …, 2015 - Am Soc Microbiol
Neuronally coexpressed ELAV/Hu proteins comprise a family of highly related RNA binding
proteins which bind to very similar cognate sequences. How this redundancy is linked to in …

Hox gene–specific cellular targeting using split intein Trojan exons

F Diao, D Vasudevan… - Proceedings of the …, 2024 - National Acad Sciences
The Trojan exon method, which makes use of intronically inserted T2A-Gal4 cassettes, has
been widely used in Drosophila to create thousands of gene-specific Gal4 driver lines …

Regulation of the alternative neural transcriptome by ELAV/Hu RNA binding proteins

L Wei, EC Lai - Frontiers in Genetics, 2022 - frontiersin.org
The process of alternative polyadenylation (APA) generates multiple 3'UTR isoforms for a
given locus, which can alter regulatory capacity and on occasion change coding potential …

Anterior-posterior gradient in neural stem and daughter cell proliferation governed by spatial and temporal Hox control

IM Cobeta, BY Salmani, S Thor - Current Biology, 2017 - cell.com
A readily evident feature of animal central nervous systems (CNSs), apparent in all
vertebrates and many invertebrates alike, is its" wedge-like" appearance, with more cells …