Environmental, mechanistic and evolutionary landscape of antibiotic persistence

C Bollen, E Louwagie, N Verstraeten, J Michiels… - EMBO …, 2023 - embopress.org
Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and
contributing to the spread of antibiotic resistance, thereby threatening the successful …

Advances in linking single-cell bacterial stress response to population-level survival

RN Alnahhas, MJ Dunlop - Current opinion in biotechnology, 2023 - Elsevier
Highlights•Heterogeneity in phenotype and growth rate of single cells affect stress
survival.•Single-cell stress responses in biofilms and interspecies interactions can alter …

(P) ppGpp synthetase Rsh participates in rifampicin tolerance of persister cells in Brucella abortus in vitro

X Liu, P Wang, Y Shi, Y Cui, S Li, GW Dong, J Li… - Microbial …, 2023 - Elsevier
Brucella abortus is facultative intracellular pathogen that causes chronic persistent infections
and results in abortion and infertility in food animals. Recurrent infections can be one of the …

Roseateles albus sp. nov., Roseateles koreensis sp. nov. and Janthinobacterium fluminis sp. nov., isolated from freshwater at Jucheon River, and emended …

S Park, I Kim, G Chhetri, Y So… - … of Systematic and …, 2023 - microbiologyresearch.org
Three Gram-stain-negative, facultatively anaerobic, rod-shaped, catalase-positive, oxidase-
negative bacterial strains were designated as hw1T, hw8T and hw3T. Strains hw1T, hw8T …

A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine

S Li, KY Hsieh, CI Kuo, TC Lin, SH Lee… - Nature …, 2023 - nature.com
Many AAA+ (ATPases associated with diverse cellular activities) proteins function as protein
or DNA remodelers by threading the substrate through the central pore of their hexameric …

Fluoroquinolone and beta-lactam antimicrobials induce different transcriptome profiles in Salmonella enterica persister cells

SP Mattiello, VC Barth Jr, J Scaria, CAS Ferreira… - Scientific Reports, 2023 - nature.com
Here, we investigate the transcriptome profiles of two S. Enteritidis and one S.
Schwarzengrund isolates that present different persister levels when exposed to …

Cellular self-digestion and persistence in Bacteria

SG Mohiuddin, S Ghosh, HG Ngo, S Sensenbach… - Microorganisms, 2021 - mdpi.com
Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells
that enables survival under stressful conditions by recycling essential energy molecules …

Exploring the links between SOS response, mutagenesis, and resistance during the recovery period

S Ghosh, MA Orman - Antimicrobial Agents and Chemotherapy, 2024 - Am Soc Microbiol
Although the mechanistic connections between SOS-induced mutagenesis and antibiotic
resistance are well established, our current understanding of the impact of SOS response …

[HTML][HTML] Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance

O Inostroza, JA Fuentes, P Yáñez, G Espinoza, O Fica… - Microorganisms, 2024 - mdpi.com
Clostridioides difficile is a Gram-positive pathogen known for its toxin production and spore
formation. It is primarily responsible for most cases of antibiotic-associated diarrhea …

Resuscitation dynamics reveal persister partitioning after antibiotic treatment

X Fang, KR Allison - Molecular systems biology, 2023 - embopress.org
Bacteria can survive antibiotics by forming dormant, drug‐tolerant persisters. Persisters can
resuscitate from dormancy after treatment and prolong infections. Resuscitation is thought to …