In the last decade, research on acute respiratory distress syndrome (ARDS) has made
considerable progress. However, ARDS remains a leading cause of mortality in the …

Acute lung injury (ALI) is a clinical disease marked by respiratory failure due to disruption of
the epithelial and endothelial barrier, flooding of the alveolar compartment with protein-rich …

Studies in humans and animal models have demonstrated that acute kidney injury (AKI) has
a significant effect on the function of extrarenal organs. The combination of AKI and lung …

Cystic fibrosis (CF) is a genetic disease in which the battle between pulmonary infection and
inflammation becomes the major cause of morbidity and mortality. We have previously …

Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased
NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase …

Despite encouraging preclinical data, therapies to reduce ARDS mortality remains a globally
unmet need, including during the COVID-19 pandemic. We previously identified …

ABSTRACT Approximately 15%-20% of patients infected with SARS-CoV-2 coronavirus
(COVID-19) progress beyond mild and self-limited disease to require supplemental oxygen …

Long pentraxin 3 (PTX3) is a newly discovered acute phase protein produced at the sites of
infection and inflammation by tissue cells, macrophages, monocytes, and dendritic cells …

Mechanical force significantly modulates both inflammation and fibrosis, yet the fundamental
mechanisms that regulate these interactions remain poorly understood. Here we performed …

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …