Advances in molecular methods have massively facilitated the discovery of potential
molecular targets for gene-specific therapy. Accelerated lead discovery has at the same time …

Recent clinical successes with antibodies have reinvigorated interest in the identification
and validation of new antigens for antibody therapy, including cell surface proteins for …

One purpose of the biomedical literature is to report results in sufficient detail that the
methods of data collection and analysis can be independently replicated and verified. Here …

Abstract The Stanford Tissue Microarray Database (TMAD; http://tma. stanford. edu) is a
public resource for disseminating annotated tissue images and associated expression data …

Over the past twenty years there have been great advances in light microscopy with the
result that multidimensional imaging has driven a revolution in modern biology. The …

Tissue microarrays (TMA s) represent a powerful method for undertaking large‐scale tissue‐
based biomarker studies. While TMA s offer several advantages, there are a number of …

BACKGROUND Human intestinal trefoil factor 3 (TFF3) is a member of a family of
polypeptides encoded by a cluster of genes on chromosome 21. Through gene expression …

Objective and design The design and implementation of ImageMiner, a software platform for
performing comparative analysis of expression patterns in imaged microscopy specimens …

Case studies of twelve existing human biospecimen repositories performed to evaluate their
utility for genomics-and proteomics-based cancer research and to identify" best practices" in …

Immunohistochemistry (IHC) provides valuable information on expression of proteins within
tissues at a cellular and subcellular level. Recent developments in the practice of IHC now …