The pharmacology and therapeutic applications of monoclonal antibodies
MS Castelli, P McGonigle… - Pharmacology research & …, 2019 - Wiley Online Library
Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the
market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 …
market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 …
Physicochemical stability of monoclonal antibodies: a review
Y Le Basle, P Chennell, N Tokhadze, A Astier… - Journal of …, 2020 - Elsevier
Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …
[HTML][HTML] Recent advances in (therapeutic protein) drug development
HAD Lagassé, A Alexaki, VL Simhadri… - …, 2017 - ncbi.nlm.nih.gov
Therapeutic protein drugs are an important class of medicines serving patients most in need
of novel therapies. Recently approved recombinant protein therapeutics have been …
of novel therapies. Recently approved recombinant protein therapeutics have been …
[HTML][HTML] The molecular mechanisms that underlie the immune biology of anti-drug antibody formation following treatment with monoclonal antibodies
A Vaisman-Mentesh, M Gutierrez-Gonzalez… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …
however, the repeated administration of mAbs can be highly immunogenic. Drug …
[HTML][HTML] Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer
NJ Ganson, TJ Povsic, BA Sullenger… - Journal of Allergy and …, 2016 - jacionline.org
In a broad investigation into a cause for these 3 events (detailed in Methods in this article's
Online Repository at www. jacionline. org), a clinical database review found no other serious …
Online Repository at www. jacionline. org), a clinical database review found no other serious …
Emerging strategies for developing next-generation protein therapeutics for cancer treatment
JR Kintzing, MVF Interrante, JR Cochran - Trends in pharmacological …, 2016 - cell.com
Protein-based therapeutics have been revolutionizing the oncology space since they first
appeared in the clinic two decades ago. Unlike traditional small-molecule …
appeared in the clinic two decades ago. Unlike traditional small-molecule …
[HTML][HTML] Nanosized delivery systems for therapeutic proteins: Clinically validated technologies and advanced development strategies
F Moncalvo, MI Martinez Espinoza… - … in bioengineering and …, 2020 - frontiersin.org
The impact of protein therapeutics in healthcare is steadily increasing, due to advancements
in the field of biotechnology and a deeper understanding of several pathologies. However …
in the field of biotechnology and a deeper understanding of several pathologies. However …
Modulating the immune system through nanotechnology
Nowadays, nanotechnology-based modulation of the immune system is presented as a
cutting-edge strategy, which may lead to significant improvements in the treatment of severe …
cutting-edge strategy, which may lead to significant improvements in the treatment of severe …
[HTML][HTML] A literature review of real-world effectiveness and safety of dupilumab for atopic dermatitis
M Kamata, Y Tada - JID Innovations, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disease with pruritus, characterized by
recurrent eczema with exacerbations and remissions. AD impairs patients' QOL and places …
recurrent eczema with exacerbations and remissions. AD impairs patients' QOL and places …
Protein-based therapeutic killing for cancer therapies
The treatment of some high-incidence human diseases is based on therapeutic cell killing.
In cancer this is mainly achieved by chemical drugs that are systemically administered to …
In cancer this is mainly achieved by chemical drugs that are systemically administered to …