Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside
in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define …

Plasma cells are unique immune effectors, capable of producing large amounts of high-
affinity antibodies that protect against pathogenic infections. Although most plasma cells …

The gut immune system is shaped by the continuous interaction with the microbiota. Here
we dissect temporal, spatial and contextual layers of gut B cell responses. The microbiota …

Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are
reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of …

Antibodies are produced across multiple isotypes with distinct properties that coordinate
initial antigen clearance and confer long-term antigen-specific immune protection. Here, we …

Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host
defense against pathogens and in mucosal immunoregulation. Whereas intense research …

Highlights•Specialized plasma cells (PCs) reside in multiple tissues throughout the body.•A
clonally related network of Immunoglobulin (Ig) A PCs occurs at mucosal sites.•Bone marrow …

The secret to longevity, plasma cell style | Nature Immunology Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

The increasing prevalence of food allergy and related pathologies in recent years has
underscored the need to understand the factors affecting adverse reactions to food. Food …

Importance Rituximab is emerging as a promising therapeutic option for systemic sclerosis
(SSc), but its long-term outcomes and response markers are unknown. Objective To …