Cutaneous melanoma: a review of multifactorial pathogenesis, immunohistochemistry, and emerging biomarkers for early detection and management

LM Gosman, DA Țăpoi, M Costache - International Journal of Molecular …, 2023 - mdpi.com
Cutaneous melanoma (CM) is an increasingly significant public health concern. Due to
alarming mortality rates and escalating incidence, it is crucial to understand its etiology and …

Exploring the complex and multifaceted interplay between melanoma cells and the tumor microenvironment

M Kuras - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous
nature and high metastatic potential. The incidence of melanoma is continuously increasing …

Metastatic Nodular Melanoma with Angiosarcomatous Transdifferentiation—A Case Report and Review of the Literature

AV Dumitru, DA Țăpoi, M Costache, AM Ciongariu… - Diagnostics, 2024 - mdpi.com
Diagnosing cutaneous melanomas relies mainly on histopathological analysis, which, in
selected cases, can be aided by immunohistochemical evaluation of conventional …

Role of a Polyphenol-Enriched Blueberry Preparation on Inhibition of Melanoma Cancer Stem Cells and Modulation of MicroRNAs

N Alsadi, N Yahfoufi, C Nessim, C Matar - Biomedicines, 2024 - mdpi.com
Melanoma is a type of skin cancer known for its high mortality rate. Cancer stem cells
(CSCs) are a subpopulation of cancer cells that significantly contribute to tumour recurrence …

[HTML][HTML] Squamous Cell Carcinoma In Situ—The Importance of Early Diagnosis in Bowen Disease, Vulvar Intraepithelial Neoplasia, Penile Intraepithelial Neoplasia …

LG Scurtu, F Scurtu, SC Dumitrescu, O Simionescu - Diagnostics, 2024 - mdpi.com
Cutaneous squamous cell carcinoma (cSCC) is the second-most-prevalent malignancy in
humans. A delayed diagnosis of cSCC leads to heightened invasiveness and positive …

The Prognostic Value of Proliferative Activity in Cutaneous Melanoma: A Pilot Study Evaluating the Mitotic Rate and Ki67 Index to Predict Patient Outcomes

DA Tapoi, AA Gheorghișan-Gălățeanu, LM Gosman… - Biomedicines, 2024 - mdpi.com
Proliferative activity in cutaneous melanomas can be appreciated both histopathologically
by counting mitotic figures and immunohistochemically through the Ki67 index, but the …

[HTML][HTML] A Unique Case of High-Grade Dedifferentiated Melanoma Without a Known Primary Site

S Keating, R Machchhar, U Jain, J Lipschutz… - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Melanoma is a malignant neoplasm that arises in melanocytes, pigment-producing cells
present primarily in the skin. However, not all malignant melanomas originate from the skin …